A powerful noble, Cadis Etrama Di Raizel, has been asleep for 820 years with no knowledge of mankind's advancement and scientific successes.

At the start of the webtoon, Rai wakes up in an abandoned building in South Korea, and starts to get used to the modern world.

He goes to a school, where he reunites with his loyal servant Frankenstein. With Frankenstein's help, Rai enrolls into high school and inadvertently befriends athletic teenager Shinwoo, computer geek Ikhan, and Shinwoo's crush Yuna, and a few others.

Noblesse follows the group's often dangerous adventures against a secret organization while uncovering Rai's past.